Drug interactions
Olanzapine + Repaglinide
Severity: Moderate
Olanzapine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause hyperglycemia and may reduce the effectiveness of repaglinide. Patients may need dose adjustment or additional antidiabetic therapy.
What this interaction means in plain words
Olanzapine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Olanzapine-induced insulin resistance and impaired glucose regulation oppose repaglinide's insulin secretagogue effect.
What to do
Monitor blood glucose more often when olanzapine is started or changed. Adjust repaglinide or add other therapy based on results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Olanzapine with Repaglinide?
MediHelp rates the interaction as moderate. Olanzapine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause hyperglycemia and may reduce the effectiveness of repaglinide. Patients may need dose adjustment or additional antidiabetic therapy.
How serious is the interaction between Olanzapine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when olanzapine is started or changed. Adjust repaglinide or add other therapy based on results.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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