Drug interactions
Olanzapine + Secobarbital
Severity: Moderate
Olanzapine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination increases sedation and may deepen CNS and respiratory depression. Barbiturate induction may also reduce olanzapine concentrations and antipsychotic effect.
What this interaction means in plain words
Olanzapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression plus barbiturate induction of CYP1A2 and glucuronidation, increasing olanzapine clearance.
What to do
Monitor sedation, respiration and psychiatric symptoms. Consider increasing the olanzapine dose if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Secobarbital?
MediHelp rates the interaction as moderate. Olanzapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination increases sedation and may deepen CNS and respiratory depression. Barbiturate induction may also reduce olanzapine concentrations and antipsychotic effect.
How serious is the interaction between Olanzapine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiration and psychiatric symptoms. Consider increasing the olanzapine dose if response is lost.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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