Drug interactions
Olanzapine + Sertraline
Severity: Minor
Olanzapine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have some potential to prolong the QT interval, although the risk with each is low. Sertraline may slightly raise olanzapine levels, and combination use is common in practice and usually tolerated.
What this interaction means in plain words
Olanzapine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Small additive QT effect and weak CYP inhibition by sertraline.
What to do
No routine adjustment is needed. Obtain ECG and electrolytes if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Sertraline?
MediHelp rates the interaction as minor. Olanzapine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents have some potential to prolong the QT interval, although the risk with each is low. Sertraline may slightly raise olanzapine levels, and combination use is common in practice and usually tolerated.
How serious is the interaction between Olanzapine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Obtain ECG and electrolytes if other QT risk factors are present.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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