Drug interactions
Olanzapine + Sitagliptin
Severity: Moderate
Olanzapine and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause hyperglycemia and weight gain, which may offset the glucose-lowering effect of sitagliptin. Glycemic control may worsen in diabetic patients.
What this interaction means in plain words
Olanzapine and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: olanzapine-induced insulin resistance and metabolic effects oppose DPP-4 inhibition.
What to do
Monitor glucose and HbA1c at baseline and periodically during olanzapine treatment. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Olanzapine with Sitagliptin?
MediHelp rates the interaction as moderate. Olanzapine and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause hyperglycemia and weight gain, which may offset the glucose-lowering effect of sitagliptin. Glycemic control may worsen in diabetic patients.
How serious is the interaction between Olanzapine and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c at baseline and periodically during olanzapine treatment. Adjust the antidiabetic regimen as needed.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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