Drug interactions
Olanzapine + Sufentanil
Severity: Moderate
Olanzapine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine and opioids such as sufentanil both depress the central nervous system. Together they can cause excess sedation, hypotension and respiratory depression, especially with parenteral dosing.
What this interaction means in plain words
Olanzapine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression, with additive hypotensive effects from olanzapine alpha-blockade.
What to do
Use the lowest effective sufentanil dose and monitor sedation, respiratory rate and blood pressure, particularly in the perioperative setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Sufentanil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olanzapine
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Olanzapine with Sufentanil?
MediHelp rates the interaction as moderate. Olanzapine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine and opioids such as sufentanil both depress the central nervous system. Together they can cause excess sedation, hypotension and respiratory depression, especially with parenteral dosing.
How serious is the interaction between Olanzapine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor sedation, respiratory rate and blood pressure, particularly in the perioperative setting.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
