Drug interactions
Olanzapine + Sumatriptan
Severity: Minor
Olanzapine and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans have been reported to contribute to serotonin syndrome when combined with other serotonergic agents, and olanzapine has some serotonin receptor activity. The risk appears low, but the combination can cause agitation, tremor, hyperthermia and autonomic instability if toxicity develops.
What this interaction means in plain words
Olanzapine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism of any clinical interaction is not firmly established.
What to do
The combination can generally be used; counsel patients to report agitation, tremor, fever, sweating or diarrhea. Stop the triptan and treat if serotonin toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Olanzapine with Sumatriptan?
MediHelp rates the interaction as minor. Olanzapine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans have been reported to contribute to serotonin syndrome when combined with other serotonergic agents, and olanzapine has some serotonin receptor activity. The risk appears low, but the combination can cause agitation, tremor, hyperthermia and autonomic instability if toxicity develops.
How serious is the interaction between Olanzapine and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can generally be used; counsel patients to report agitation, tremor, fever, sweating or diarrhea. Stop the triptan and treat if serotonin toxicity occurs.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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