Drug interactions
Olanzapine + Tolazamide
Severity: Moderate
Olanzapine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause hyperglycemia and weight gain, which may reduce the effectiveness of sulfonylurea therapy such as tolazamide. Patients may need higher antidiabetic doses.
What this interaction means in plain words
Olanzapine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: olanzapine-related insulin resistance and impaired glucose regulation oppose sulfonylurea action.
What to do
Monitor blood glucose and HbA1c when olanzapine is started or adjusted. Adjust the tolazamide dose or add therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Olanzapine with Tolazamide?
MediHelp rates the interaction as moderate. Olanzapine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause hyperglycemia and weight gain, which may reduce the effectiveness of sulfonylurea therapy such as tolazamide. Patients may need higher antidiabetic doses.
How serious is the interaction between Olanzapine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when olanzapine is started or adjusted. Adjust the tolazamide dose or add therapy if control worsens.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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