Drug interactions
Olanzapine + Tranylcypromine
Severity: Moderate
Olanzapine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration may add serotonergic and dopamine-blocking effects, so serotonin toxicity or neuroleptic malignant syndrome is possible though uncommon. Olanzapine can also add sedation and orthostatic hypotension to the MAO inhibitor's own blood pressure effects.
What this interaction means in plain words
Olanzapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from MAO inhibition and olanzapine's dopamine and serotonin receptor antagonism.
What to do
Start olanzapine at a low dose and titrate slowly. Monitor for hyperthermia, rigidity, clonus, autonomic instability and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Tranylcypromine?
MediHelp rates the interaction as moderate. Olanzapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration may add serotonergic and dopamine-blocking effects, so serotonin toxicity or neuroleptic malignant syndrome is possible though uncommon. Olanzapine can also add sedation and orthostatic hypotension to the MAO inhibitor's own blood pressure effects.
How serious is the interaction between Olanzapine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start olanzapine at a low dose and titrate slowly. Monitor for hyperthermia, rigidity, clonus, autonomic instability and orthostatic hypotension.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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