Drug interactions
Olanzapine + Umeclidinium-vilanterol
Severity: Moderate
Olanzapine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small QT-prolonging effect and can cause tachycardia. Combined with vilanterol, additive cardiac effects are possible, though the risk is usually modest.
What this interaction means in plain words
Olanzapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and heart rate.
What to do
Monitor heart rate and consider ECG in patients with additional QT risk factors. Maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Olanzapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small QT-prolonging effect and can cause tachycardia. Combined with vilanterol, additive cardiac effects are possible, though the risk is usually modest.
How serious is the interaction between Olanzapine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and consider ECG in patients with additional QT risk factors. Maintain normal potassium and magnesium.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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