Drug interactions
Olanzapine + Vardenafil
Severity: Moderate
Olanzapine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small QT effect, and vardenafil may add slightly to it. The combined risk is usually low but is relevant in patients with other risk factors; olanzapine can also cause orthostatic hypotension.
What this interaction means in plain words
Olanzapine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization and possible additive hypotension.
What to do
Correct electrolyte abnormalities and monitor blood pressure and ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Vardenafil?
MediHelp rates the interaction as moderate. Olanzapine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small QT effect, and vardenafil may add slightly to it. The combined risk is usually low but is relevant in patients with other risk factors; olanzapine can also cause orthostatic hypotension.
How serious is the interaction between Olanzapine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte abnormalities and monitor blood pressure and ECG in patients with cardiac risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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