Drug interactions
Olanzapine + Verapamil
Severity: Minor
Olanzapine and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may slightly raise olanzapine levels, increasing sedation and orthostatic hypotension. Additive blood pressure lowering may also occur.
What this interaction means in plain words
Olanzapine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP1A2 metabolism of olanzapine plus additive hypotensive effects.
What to do
Monitor blood pressure and sedation when starting or adjusting either drug. Lower the olanzapine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Verapamil?
MediHelp rates the interaction as minor. Olanzapine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may slightly raise olanzapine levels, increasing sedation and orthostatic hypotension. Additive blood pressure lowering may also occur.
How serious is the interaction between Olanzapine and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation when starting or adjusting either drug. Lower the olanzapine dose if adverse effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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