Drug interactions
Olanzapine + Voclosporin
Severity: Moderate
Olanzapine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposure, and olanzapine can modestly prolong the QT interval. Combined use may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Olanzapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Check an ECG and electrolytes at baseline and monitor the QTc in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Olanzapine with Voclosporin?
MediHelp rates the interaction as moderate. Olanzapine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposure, and olanzapine can modestly prolong the QT interval. Combined use may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Olanzapine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes at baseline and monitor the QTc in patients with additional risk factors.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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