Drug interactions
Olanzapine / samidorphan + Secobarbital
Severity: Moderate
Olanzapine / samidorphan and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both secobarbital and olanzapine depress the CNS, so sedation and orthostatic hypotension may be increased. Falls and impaired alertness are the main concerns.
What this interaction means in plain words
Olanzapine / samidorphan and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects through pharmacodynamic synergism.
What to do
Monitor sedation and orthostatic blood pressure, especially at initiation. Counsel the patient on avoiding driving and rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Secobarbital?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both secobarbital and olanzapine depress the CNS, so sedation and orthostatic hypotension may be increased. Falls and impaired alertness are the main concerns.
How serious is the interaction between Olanzapine / samidorphan and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, especially at initiation. Counsel the patient on avoiding driving and rising slowly.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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