Drug interactions
Olanzapine / samidorphan + Sertraline
Severity: Moderate
Olanzapine / samidorphan and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sertraline and olanzapine can cause sedation, and olanzapine can cause orthostatic hypotension. Together they may increase drowsiness, dizziness and fall risk, especially at initiation.
What this interaction means in plain words
Olanzapine / samidorphan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive pharmacodynamic effects.
What to do
Monitor for sedation and orthostatic blood pressure changes when starting or adjusting doses. Advise patients to rise slowly and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Sertraline?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both sertraline and olanzapine can cause sedation, and olanzapine can cause orthostatic hypotension. Together they may increase drowsiness, dizziness and fall risk, especially at initiation.
How serious is the interaction between Olanzapine / samidorphan and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic blood pressure changes when starting or adjusting doses. Advise patients to rise slowly and avoid alcohol.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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