Drug interactions
Olanzapine / samidorphan + Tiotropium
Severity: Moderate
Olanzapine / samidorphan and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has notable antimuscarinic activity and can add to tiotropium effects, including constipation, urinary retention, dry mouth and tachycardia. Severe gastrointestinal hypomotility is a labeled concern with olanzapine and other anticholinergics. Systemic tiotropium exposure is low, so the effect is usually moderate.
What this interaction means in plain words
Olanzapine / samidorphan and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects reducing gastrointestinal and urinary tract motility.
What to do
Monitor bowel function and urinary symptoms, and treat constipation early. Review the need for the combination if hypomotility symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Olanzapine / samidorphan with Tiotropium?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has notable antimuscarinic activity and can add to tiotropium effects, including constipation, urinary retention, dry mouth and tachycardia. Severe gastrointestinal hypomotility is a labeled concern with olanzapine and other anticholinergics. Systemic tiotropium exposure is low, so the effect is usually moderate.
How serious is the interaction between Olanzapine / samidorphan and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms, and treat constipation early. Review the need for the combination if hypomotility symptoms develop.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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