Drug interactions
Olanzapine / samidorphan + Tranylcypromine
Severity: Moderate
Olanzapine / samidorphan and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause sedation and orthostatic hypotension, and tranylcypromine also frequently causes orthostatic hypotension. Together these effects may be additive, raising the risk of dizziness, syncope and falls.
What this interaction means in plain words
Olanzapine / samidorphan and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive and CNS depressant effects.
What to do
Monitor orthostatic blood pressure and sedation, particularly at initiation and dose increases, and counsel patients about falls and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Tranylcypromine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause sedation and orthostatic hypotension, and tranylcypromine also frequently causes orthostatic hypotension. Together these effects may be additive, raising the risk of dizziness, syncope and falls.
How serious is the interaction between Olanzapine / samidorphan and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and sedation, particularly at initiation and dose increases, and counsel patients about falls and driving.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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