Drug interactions
Olanzapine / samidorphan + Valproic acid
Severity: Moderate
Olanzapine / samidorphan and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate has been reported to lower olanzapine concentrations in some patients, which could reduce antipsychotic control. The effect is variable and the mechanism is not well established. Both drugs can also cause weight gain and sedation.
What this interaction means in plain words
Olanzapine / samidorphan and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not firmly established; possible induction of olanzapine glucuronidation by valproate.
What to do
Monitor psychiatric response and consider olanzapine dose adjustment if control worsens. Monitor weight and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Valproic acid?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproate has been reported to lower olanzapine concentrations in some patients, which could reduce antipsychotic control. The effect is variable and the mechanism is not well established. Both drugs can also cause weight gain and sedation.
How serious is the interaction between Olanzapine / samidorphan and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider olanzapine dose adjustment if control worsens. Monitor weight and metabolic parameters.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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