Drug interactions
Olanzapine / samidorphan + Verapamil
Severity: Moderate
Olanzapine / samidorphan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, and verapamil lowers blood pressure through vasodilation. Used together, they may produce additive hypotension, dizziness or syncope, particularly at initiation or after dose increases.
What this interaction means in plain words
Olanzapine / samidorphan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering from alpha-adrenergic blockade by olanzapine and calcium channel blockade by verapamil.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the verapamil dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Verapamil?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension, and verapamil lowers blood pressure through vasodilation. Used together, they may produce additive hypotension, dizziness or syncope, particularly at initiation or after dose increases.
How serious is the interaction between Olanzapine / samidorphan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the verapamil dose if symptomatic hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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