Drug interactions
Olaparib + Paclitaxel
Severity: Moderate
Olaparib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause bone marrow suppression, and combination can cause more severe or prolonged neutropenia, anemia and thrombocytopenia. Overlapping toxicity often requires dose modification.
What this interaction means in plain words
Olaparib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Additive myelosuppression through different cytotoxic mechanisms.
What to do
Check blood counts regularly and reduce doses or delay cycles for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Paclitaxel?
MediHelp rates the interaction as moderate. Olaparib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause bone marrow suppression, and combination can cause more severe or prolonged neutropenia, anemia and thrombocytopenia. Overlapping toxicity often requires dose modification.
How serious is the interaction between Olaparib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood counts regularly and reduce doses or delay cycles for significant cytopenias.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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