Drug interactions
Olaparib + Quinidine
Severity: Moderate
Olaparib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized by CYP3A4, and quinidine is a CYP3A4 inhibitor, though weaker than strong inhibitors, so olaparib exposure may increase. This may raise the risk of adverse effects such as anemia, nausea, and fatigue.
What this interaction means in plain words
Olaparib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4, reducing olaparib clearance.
What to do
Monitor blood counts and tolerability, and reduce the olaparib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Quinidine?
MediHelp rates the interaction as moderate. Olaparib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is metabolized by CYP3A4, and quinidine is a CYP3A4 inhibitor, though weaker than strong inhibitors, so olaparib exposure may increase. This may raise the risk of adverse effects such as anemia, nausea, and fatigue.
How serious is the interaction between Olaparib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability, and reduce the olaparib dose if adverse effects occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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