Drug interactions
Olaparib + Sertraline
Severity: Minor
Olaparib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is cleared mainly by CYP3A4, and inhibitors can raise its levels and increase haematological toxicity. Sertraline is a weak CYP3A4 inhibitor, so the effect is expected to be limited.
What this interaction means in plain words
Olaparib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olaparib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reducing olaparib metabolism.
What to do
No dose change is usually needed; monitor blood counts as per routine olaparib care. Reduce the dose only if marked toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Sertraline?
MediHelp rates the interaction as minor. Olaparib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olaparib is cleared mainly by CYP3A4, and inhibitors can raise its levels and increase haematological toxicity. Sertraline is a weak CYP3A4 inhibitor, so the effect is expected to be limited.
How serious is the interaction between Olaparib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood counts as per routine olaparib care. Reduce the dose only if marked toxicity appears.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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