Drug interactions
Olaparib + Ticagrelor
Severity: Minor
Olaparib and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized by CYP3A4, and ticagrelor is a weak CYP3A inhibitor that may modestly raise olaparib levels. This could increase hematologic toxicity such as anemia and thrombocytopenia, which also matters for bleeding risk on ticagrelor.
What this interaction means in plain words
Olaparib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olaparib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor may slightly reduce olaparib clearance.
What to do
Monitor blood counts and for bleeding. No empirical olaparib dose reduction is generally needed for a weak inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Ticagrelor?
MediHelp rates the interaction as minor. Olaparib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olaparib is metabolized by CYP3A4, and ticagrelor is a weak CYP3A inhibitor that may modestly raise olaparib levels. This could increase hematologic toxicity such as anemia and thrombocytopenia, which also matters for bleeding risk on ticagrelor.
How serious is the interaction between Olaparib and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for bleeding. No empirical olaparib dose reduction is generally needed for a weak inhibitor.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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