Drug interactions
Olaparib + Topotecan
Severity: Major
Olaparib and Topotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause bone marrow suppression, and combining them can lead to more severe and prolonged neutropenia, anemia and thrombocytopenia. Combination regimens usually require dose reductions.
What this interaction means in plain words
Olaparib and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olaparib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Additive myelosuppression, with PARP inhibition potentiating topoisomerase I inhibitor DNA damage.
What to do
Use only within a monitored protocol, with frequent complete blood counts and reduced doses of one or both drugs. Delay treatment or use growth factor support for significant cytopenias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Topotecan?
MediHelp rates the interaction as major. Olaparib and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents cause bone marrow suppression, and combining them can lead to more severe and prolonged neutropenia, anemia and thrombocytopenia. Combination regimens usually require dose reductions.
How serious is the interaction between Olaparib and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only within a monitored protocol, with frequent complete blood counts and reduced doses of one or both drugs. Delay treatment or use growth factor support for significant cytopenias.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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