Drug interactions
Olaparib + Vinblastine
Severity: Moderate
Olaparib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, and combining them can lead to more frequent or prolonged anaemia, neutropenia and thrombocytopenia. Olaparib may also cause myelodysplastic syndrome with prolonged use.
What this interaction means in plain words
Olaparib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Additive myelosuppression through different cytotoxic mechanisms.
What to do
Monitor complete blood counts regularly and reduce doses or delay treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Vinblastine?
MediHelp rates the interaction as moderate. Olaparib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, and combining them can lead to more frequent or prolonged anaemia, neutropenia and thrombocytopenia. Olaparib may also cause myelodysplastic syndrome with prolonged use.
How serious is the interaction between Olaparib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce doses or delay treatment for significant cytopenias.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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