Drug interactions
Oliceridine + Phenytoin
Severity: Moderate
Oliceridine and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and can reduce oliceridine exposure, leading to weaker analgesia. If phenytoin is stopped, oliceridine levels rise and may cause respiratory depression.
What this interaction means in plain words
Oliceridine and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing oliceridine clearance.
What to do
Titrate oliceridine to effect and monitor for inadequate analgesia. Reduce the dose and watch for respiratory depression if phenytoin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Phenytoin?
MediHelp rates the interaction as moderate. Oliceridine and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP3A4 and can reduce oliceridine exposure, leading to weaker analgesia. If phenytoin is stopped, oliceridine levels rise and may cause respiratory depression.
How serious is the interaction between Oliceridine and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to effect and monitor for inadequate analgesia. Reduce the dose and watch for respiratory depression if phenytoin is discontinued.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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