Drug interactions
Oliceridine + Trihexyphenidyl
Severity: Moderate
Oliceridine and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastrointestinal transit and can cause urinary retention, and trihexyphenidyl adds anticholinergic effects on the same systems. Together they can lead to severe constipation, paralytic ileus and urinary retention.
What this interaction means in plain words
Oliceridine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive reduction of gut and bladder motility via opioid receptor activation and muscarinic blockade.
What to do
Monitor for constipation, abdominal distension and urinary retention, and start a prophylactic bowel regimen; reduce or stop the anticholinergic if ileus is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trihexyphenidyl
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Oliceridine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastrointestinal transit and can cause urinary retention, and trihexyphenidyl adds anticholinergic effects on the same systems. Together they can lead to severe constipation, paralytic ileus and urinary retention.
How serious is the interaction between Oliceridine and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, abdominal distension and urinary retention, and start a prophylactic bowel regimen; reduce or stop the anticholinergic if ileus is suspected.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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