Drug interactions
Oliceridine + Venlafaxine
Severity: Moderate
Oliceridine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and the labeling warns of serotonin syndrome with serotonergic drugs. Venlafaxine increases serotonin, so the combination may contribute to serotonin toxicity. Additive CNS and respiratory depression is also possible.
What this interaction means in plain words
Oliceridine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with possible additive CNS depression.
What to do
Monitor for serotonin syndrome, especially after starting or increasing doses. Stop the serotonergic drugs if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Venlafaxine?
MediHelp rates the interaction as moderate. Oliceridine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid and the labeling warns of serotonin syndrome with serotonergic drugs. Venlafaxine increases serotonin, so the combination may contribute to serotonin toxicity. Additive CNS and respiratory depression is also possible.
How serious is the interaction between Oliceridine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially after starting or increasing doses. Stop the serotonergic drugs if symptoms develop.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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