Drug interactions
Oliceridine + Zolpidem
Severity: Major
Oliceridine and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedative-hypnotic can cause profound sedation, respiratory depression, coma and death. Regulators have issued warnings for opioids with benzodiazepines and other CNS depressants.
What this interaction means in plain words
Oliceridine and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through mu-opioid agonism and GABA-A potentiation.
What to do
Reserve concomitant use for patients without alternatives, using the lowest doses and shortest durations, and monitor closely for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Zolpidem?
MediHelp rates the interaction as major. Oliceridine and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a sedative-hypnotic can cause profound sedation, respiratory depression, coma and death. Regulators have issued warnings for opioids with benzodiazepines and other CNS depressants.
How serious is the interaction between Oliceridine and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concomitant use for patients without alternatives, using the lowest doses and shortest durations, and monitor closely for respiratory depression and sedation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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