Drug interactions
Olmesartan + Sulindac
Severity: Major
Olmesartan and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Olmesartan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olmesartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAIDs block prostaglandin-mediated afferent arteriolar dilation while the ARB dilates the efferent arteriole, reducing glomerular filtration pressure; both also impair potassium excretion.
What to do
Ensure adequate hydration and monitor serum creatinine and potassium within the first weeks of combined use and after dose changes. Avoid the combination in patients with volume depletion or advanced renal disease where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Olmesartan with Sulindac?
MediHelp rates the interaction as major. Olmesartan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Olmesartan and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine and potassium within the first weeks of combined use and after dose changes. Avoid the combination in patients with volume depletion or advanced renal disease where possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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