Drug interactions
Olmesartan + Tolfenamic acid
Severity: Moderate
Olmesartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can reduce the antihypertensive effect of angiotensin receptor blockers and impair renal function. In volume-depleted, elderly or renally impaired patients this can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Olmesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion, which with ARB blockade of efferent arteriolar tone impairs glomerular filtration and potassium excretion.
What to do
Use the lowest effective NSAID dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Olmesartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Olmesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can reduce the antihypertensive effect of angiotensin receptor blockers and impair renal function. In volume-depleted, elderly or renally impaired patients this can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Olmesartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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