Drug interactions
Olmesartan + Treprostinil
Severity: Moderate
Olmesartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator, and with olmesartan the blood pressure lowering effects are additive. Symptomatic hypotension may occur, particularly at initiation or dose increases.
What this interaction means in plain words
Olmesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure reduction.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug, and reduce the dose of olmesartan if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Olmesartan with Treprostinil?
MediHelp rates the interaction as moderate. Olmesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a vasodilator, and with olmesartan the blood pressure lowering effects are additive. Symptomatic hypotension may occur, particularly at initiation or dose increases.
How serious is the interaction between Olmesartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug, and reduce the dose of olmesartan if needed.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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