Drug interactions
Olmesartan + Voclosporin
Severity: Major
Olmesartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and nephrotoxicity, and olmesartan adds to these effects through efferent arteriolar dilation and reduced potassium excretion. The combination raises risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Olmesartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olmesartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal hemodynamic effects and reduced potassium excretion from calcineurin inhibition and angiotensin receptor blockade.
What to do
Monitor eGFR and serum potassium frequently, especially after initiation and dose changes. Reduce or stop either agent if renal function declines or hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Olmesartan with Voclosporin?
MediHelp rates the interaction as major. Olmesartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and nephrotoxicity, and olmesartan adds to these effects through efferent arteriolar dilation and reduced potassium excretion. The combination raises risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Olmesartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium frequently, especially after initiation and dose changes. Reduce or stop either agent if renal function declines or hyperkalemia occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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