Drug interactions
Olodaterol inhaled + Ziprasidone
Severity: Moderate
Olodaterol inhaled and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone prolongs the QT interval, and long-acting beta-2 agonists can cause tachycardia and hypokalemia. Together they may raise the risk of ventricular arrhythmias, especially with other risk factors.
What this interaction means in plain words
Olodaterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiac effects: QT prolongation with beta-2 agonist mediated tachycardia and hypokalemia.
What to do
Check ECG and electrolytes at baseline in patients at risk. Correct potassium and magnesium and report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Ziprasidone?
MediHelp rates the interaction as moderate. Olodaterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone prolongs the QT interval, and long-acting beta-2 agonists can cause tachycardia and hypokalemia. Together they may raise the risk of ventricular arrhythmias, especially with other risk factors.
How serious is the interaction between Olodaterol inhaled and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline in patients at risk. Correct potassium and magnesium and report palpitations or syncope.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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