Drug interactions
Olopatadine intranasal + Oxymorphone
Severity: Moderate
Olopatadine intranasal and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, which may add to opioid-induced sedation. Psychomotor impairment and daytime drowsiness may be increased.
What this interaction means in plain words
Olopatadine intranasal and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistamine sedation and opioid agonism.
What to do
Counsel patients about drowsiness and driving, and monitor for sedation. Consider a less sedating alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Olopatadine intranasal with Oxymorphone?
MediHelp rates the interaction as moderate. Olopatadine intranasal and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, which may add to opioid-induced sedation. Psychomotor impairment and daytime drowsiness may be increased.
How serious is the interaction between Olopatadine intranasal and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving, and monitor for sedation. Consider a less sedating alternative.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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