Drug interactions
Olutasidenib + Praziquantel
Severity: Moderate
Olutasidenib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower praziquantel levels. This may reduce antiparasitic efficacy.
What this interaction means in plain words
Olutasidenib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olutasidenib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by olutasidenib accelerates praziquantel metabolism.
What to do
Monitor for treatment failure and consider follow-up testing after therapy. Seek an alternative anthelmintic strategy if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Praziquantel?
MediHelp rates the interaction as moderate. Olutasidenib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olutasidenib induces CYP3A4 and may lower praziquantel levels. This may reduce antiparasitic efficacy.
How serious is the interaction between Olutasidenib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and consider follow-up testing after therapy. Seek an alternative anthelmintic strategy if the response is inadequate.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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