Drug interactions
Olutasidenib + Quinine
Severity: Major
Olutasidenib and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and can lower quinine plasma concentrations. Reduced exposure may lead to treatment failure in malaria, a potentially serious infection.
What this interaction means in plain words
Olutasidenib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olutasidenib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Olutasidenib induces hepatic and intestinal CYP3A4, increasing the metabolism of quinine.
What to do
Avoid the combination where possible and choose an alternative antimalarial. If it cannot be avoided, monitor closely for parasitological or clinical failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olutasidenib and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Quinine?
MediHelp rates the interaction as major. Olutasidenib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4 and can lower quinine plasma concentrations. Reduced exposure may lead to treatment failure in malaria, a potentially serious infection.
How serious is the interaction between Olutasidenib and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antimalarial. If it cannot be avoided, monitor closely for parasitological or clinical failure.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
