Drug interactions
Omacetaxine + Warfarin
Severity: Major
Omacetaxine and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omacetaxine commonly causes thrombocytopenia and carries a bleeding risk, including serious hemorrhage. Anticoagulation with warfarin adds to this risk, especially when platelets are low. It is not an absolute contraindication but needs careful control.
What this interaction means in plain words
Omacetaxine and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bleeding risk from omacetaxine-induced thrombocytopenia and warfarin's anticoagulant effect.
What to do
Avoid anticoagulants when platelets are below about 50 x10^9/L and monitor blood counts frequently. Check INR closely and adjust warfarin dosing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Omacetaxine with Warfarin?
MediHelp rates the interaction as major. Omacetaxine and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omacetaxine commonly causes thrombocytopenia and carries a bleeding risk, including serious hemorrhage. Anticoagulation with warfarin adds to this risk, especially when platelets are low. It is not an absolute contraindication but needs careful control.
How serious is the interaction between Omacetaxine and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticoagulants when platelets are below about 50 x10^9/L and monitor blood counts frequently. Check INR closely and adjust warfarin dosing.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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