Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Propafenone
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and CYP2D6, both involved in propafenone metabolism, so propafenone levels can rise considerably. This increases the risk of conduction abnormalities and ventricular arrhythmias.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir inhibits CYP2D6 and CYP3A4, reducing propafenone clearance.
What to do
Avoid the combination or use a reduced propafenone dose with ECG monitoring and plasma concentration monitoring where available. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Propafenone?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir inhibits CYP3A4 and CYP2D6, both involved in propafenone metabolism, so propafenone levels can rise considerably. This increases the risk of conduction abnormalities and ventricular arrhythmias.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or use a reduced propafenone dose with ECG monitoring and plasma concentration monitoring where available. Consider an alternative antiarrhythmic.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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