Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Quetiapine
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted paritaprevir strongly inhibits CYP3A4 and can greatly increase quetiapine exposure. This may cause profound sedation, hypotension and QT prolongation.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition by ritonavir (and paritaprevir) reduces quetiapine clearance.
What to do
Consider alternative HCV therapy. If it must be given with quetiapine, reduce the quetiapine dose considerably, and monitor for sedation, blood pressure and ECG changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Quetiapine?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted paritaprevir strongly inhibits CYP3A4 and can greatly increase quetiapine exposure. This may cause profound sedation, hypotension and QT prolongation.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative HCV therapy. If it must be given with quetiapine, reduce the quetiapine dose considerably, and monitor for sedation, blood pressure and ECG changes.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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