Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Saxagliptin-metformin
Severity: Moderate
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens strongly inhibit CYP3A4, which can increase saxagliptin exposure. Metformin exposure may also be affected, and lactic acidosis risk is higher with renal or hepatic impairment.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir inhibits CYP3A4 and may affect transporter-mediated metformin disposition.
What to do
Limit saxagliptin to 2.5 mg daily and monitor for lactic acidosis symptoms and renal function. Monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens strongly inhibit CYP3A4, which can increase saxagliptin exposure. Metformin exposure may also be affected, and lactic acidosis risk is higher with renal or hepatic impairment.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily and monitor for lactic acidosis symptoms and renal function. Monitor blood glucose.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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