Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Simvastatin
Severity: Contraindicated
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Simvastatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This hepatitis C regimen raises simvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The combination is contraindicated.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4 and OATP1B1, reducing the metabolism and hepatic uptake of simvastatin.
What to do
Do not co-administer; hold simvastatin during the regimen or use a low-dose alternative like rosuvastatin or pravastatin with monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Simvastatin?
MediHelp rates the interaction as contraindicated. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This hepatitis C regimen raises simvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The combination is contraindicated.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold simvastatin during the regimen or use a low-dose alternative like rosuvastatin or pravastatin with monitoring.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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