Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Tamsulosin
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir and paritaprevir inhibit CYP3A4 and CYP2D6, which can substantially raise tamsulosin exposure. This increases the risk of hypotension, dizziness and syncope.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir-containing regimen inhibits CYP3A4 and CYP2D6, reducing tamsulosin clearance.
What to do
Avoid if possible, or hold tamsulosin during the HCV regimen. If continued, monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Tamsulosin?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir and paritaprevir inhibit CYP3A4 and CYP2D6, which can substantially raise tamsulosin exposure. This increases the risk of hypotension, dizziness and syncope.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or hold tamsulosin during the HCV regimen. If continued, monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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