Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Verapamil
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted paritaprevir strongly inhibits CYP3A4 and can substantially raise verapamil concentrations. This may cause hypotension, bradycardia, AV block and peripheral edema.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4 (and P-glycoprotein), reducing verapamil clearance.
What to do
Reduce the verapamil dose and monitor heart rate, blood pressure, ECG and edema. Consider switching to an alternative antihypertensive if adverse effects occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Verapamil?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted paritaprevir strongly inhibits CYP3A4 and can substantially raise verapamil concentrations. This may cause hypotension, bradycardia, AV block and peripheral edema.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the verapamil dose and monitor heart rate, blood pressure, ECG and edema. Consider switching to an alternative antihypertensive if adverse effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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