Drug interactions
Ombitasvir / paritaprevir / ritonavir + Secobarbital
Severity: Major
Ombitasvir / paritaprevir / ritonavir and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower concentrations of paritaprevir and ritonavir through CYP3A4 induction. Subtherapeutic antiviral levels could cause virologic failure and resistance.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 increases metabolism of paritaprevir and ritonavir, lowering antiviral exposure.
What to do
Avoid the combination and use a non-inducing hypnotic during hepatitis C therapy. Monitor HCV RNA response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir with Secobarbital?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may lower concentrations of paritaprevir and ritonavir through CYP3A4 induction. Subtherapeutic antiviral levels could cause virologic failure and resistance.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing hypnotic during hepatitis C therapy. Monitor HCV RNA response if it cannot be avoided.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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