Drug interactions
Opium tincture + Procarbazine
Severity: Major
Opium tincture and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibiting activity, and opioids such as morphine in opium tincture can cause serotonin toxicity or exaggerated CNS and respiratory depression and hypotension when combined with MAOIs.
What this interaction means in plain words
Opium tincture and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may potentiate opioid CNS depression and serotonergic effects; mechanism not fully defined.
What to do
Avoid during procarbazine therapy and for 14 days after stopping. If needed, use small doses with close monitoring of blood pressure and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Opium tincture with Procarbazine?
MediHelp rates the interaction as major. Opium tincture and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has MAO inhibiting activity, and opioids such as morphine in opium tincture can cause serotonin toxicity or exaggerated CNS and respiratory depression and hypotension when combined with MAOIs.
How serious is the interaction between Opium tincture and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during procarbazine therapy and for 14 days after stopping. If needed, use small doses with close monitoring of blood pressure and respiration.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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