Drug interactions
Opium tincture + Thioridazine
Severity: Moderate
Opium tincture and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine, and combining it with thioridazine increases sedation and may add to respiratory depression and hypotension. The risk is greatest in elderly or debilitated patients and with higher doses.
What this interaction means in plain words
Opium tincture and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system and respiratory depression from an opioid and a sedating phenothiazine.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Opium tincture with Thioridazine?
MediHelp rates the interaction as moderate. Opium tincture and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine, and combining it with thioridazine increases sedation and may add to respiratory depression and hypotension. The risk is greatest in elderly or debilitated patients and with higher doses.
How serious is the interaction between Opium tincture and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if excessive drowsiness occurs.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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