Drug interactions
Opium tincture + Ziprasidone
Severity: Moderate
Opium tincture and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and can cause sedation and respiratory depression, which may be increased by ziprasidone. Hypotension and impaired psychomotor function may also be increased.
What this interaction means in plain words
Opium tincture and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Opium tincture with Ziprasidone?
MediHelp rates the interaction as moderate. Opium tincture and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine and can cause sedation and respiratory depression, which may be increased by ziprasidone. Hypotension and impaired psychomotor function may also be increased.
How serious is the interaction between Opium tincture and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients on avoiding driving and alcohol.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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