Drug interactions
Oritavancin + Phenytoin
Severity: Minor
Oritavancin and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oritavancin is a weak CYP2C9 inhibitor and may modestly raise phenytoin levels. It is given as a single dose, so any effect is likely transient.
What this interaction means in plain words
Oritavancin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oritavancin belongs to Anti Bacterial; Phenytoin belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2C9 by oritavancin reduces phenytoin metabolism.
What to do
Monitor for signs of phenytoin toxicity after oritavancin dosing and check a level if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Oritavancin
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
Frequently asked questions
Can I take Oritavancin with Phenytoin?
MediHelp rates the interaction as minor. Oritavancin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oritavancin is a weak CYP2C9 inhibitor and may modestly raise phenytoin levels. It is given as a single dose, so any effect is likely transient.
How serious is the interaction between Oritavancin and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of phenytoin toxicity after oritavancin dosing and check a level if symptoms appear.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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