Drug interactions
Cyclosporin + Oritavancin
Severity: Minor
Cyclosporin and Oritavancin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oritavancin is a weak CYP3A4 inducer and could slightly lower cyclosporine concentrations. Clinical significance is uncertain, but cyclosporine has a narrow therapeutic index so loss of immunosuppression is a theoretical concern.
What this interaction means in plain words
Cyclosporin and Oritavancin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Oritavancin belongs to Anti Bacterial.
Why it happens
Weak induction of CYP3A4 by oritavancin may modestly increase cyclosporine metabolism.
What to do
Check cyclosporine trough concentrations during and shortly after oritavancin treatment. Adjust the dose only if levels fall below target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Oritavancin
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
- Oritavancin + Phenytoin Minor
Frequently asked questions
Can I take Cyclosporin with Oritavancin?
MediHelp rates the interaction as minor. Cyclosporin and Oritavancin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oritavancin is a weak CYP3A4 inducer and could slightly lower cyclosporine concentrations. Clinical significance is uncertain, but cyclosporine has a narrow therapeutic index so loss of immunosuppression is a theoretical concern.
How serious is the interaction between Cyclosporin and Oritavancin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check cyclosporine trough concentrations during and shortly after oritavancin treatment. Adjust the dose only if levels fall below target.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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