Drug interactions
Flecainide + Oritavancin
Severity: Minor
Flecainide and Oritavancin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oritavancin is a weak CYP2D6 inducer and could slightly lower flecainide concentrations, potentially reducing efficacy. The effect is likely small and short-lived.
What this interaction means in plain words
Flecainide and Oritavancin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flecainide belongs to Cardiovascular; Oritavancin belongs to Anti Bacterial.
Why it happens
Weak induction of CYP2D6 may increase flecainide clearance.
What to do
Monitor for loss of arrhythmia control during and after oritavancin. Check flecainide levels if breakthrough arrhythmias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Oritavancin
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Oritavancin + Phenytoin Minor
Frequently asked questions
Can I take Flecainide with Oritavancin?
MediHelp rates the interaction as minor. Flecainide and Oritavancin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oritavancin is a weak CYP2D6 inducer and could slightly lower flecainide concentrations, potentially reducing efficacy. The effect is likely small and short-lived.
How serious is the interaction between Flecainide and Oritavancin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of arrhythmia control during and after oritavancin. Check flecainide levels if breakthrough arrhythmias occur.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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